Regulation of B cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of B cell receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, FMNL1_S1031, and GIMAP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell receptor signaling pathway activity versus FMNL1 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FMNL1 →	+0.549	+0.776	<.001	<.001	3	6
LSCC	FMNL1_S1031 →	+0.735	+0.927	<.001	<.001	3	6
LSCC	GIMAP4 →	+0.543	+0.868	<.001	<.001	3	6
BRCA	IKZF1_S63 →	+0.889	+0.866	<.001	<.001	3	6
LSCC	NCKAP1L →	+0.483	+0.708	<.001	<.001	3	6
LSCC	ARHGAP15_S64 →	+0.887	+0.625	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050855 vs FMNL1 — LSCC

Explore this scatter interactively →