Regulation of B cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of B cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC122, MIR1915HG, and TRIP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell receptor signaling pathway activity versus CCDC122 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCDC122 →	+1.282	+0.965	.001	.003	3	4
BLOOD_Lymphoma	MIR1915HG →	-0.588	-1.773	<.001	<.001	3	4
PANCREAS	TRIP10 →	+0.971	+0.306	.005	.001	3	4
BLOOD_Lymphoma	LPXN →	+1.933	+1.561	<.001	<.001	3	3
BLOOD_Leukemia	CLCN2 →	-0.579	-0.886	.003	.001	3	3
BLOOD_Lymphoma	ACY3 →	+2.401	+1.289	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050855 vs CCDC122 — BLOOD_Lymphoma

Explore this scatter interactively →