Regulation of antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA2, STX11, and FYB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antigen receptor-mediated signaling pathway activity versus SLA2 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLA2 →	+0.742	+0.326	<.001	.004	3	8
HNSC	STX11 →	+0.580	+0.376	<.001	.005	3	7
LSCC	FYB1 →	+0.987	+0.404	<.001	<.001	3	7
LSCC	RASAL3 →	+0.721	+0.359	<.001	<.001	3	7
LSCC	GNGT2 →	+0.558	+0.319	<.001	.003	3	7
LSCC	NCR1 →	+0.494	+0.407	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050854 vs SLA2 — HNSC

Explore this scatter interactively →