Regulation of antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FICD, ZNF540, and ITGAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antigen receptor-mediated signaling pathway activity versus FICD in SOFT_TISSUE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FICD →	+0.762	+0.247	.001	.005	3	4
BLOOD_Lymphoma	ZNF540 →	+1.010	+0.353	<.001	<.001	3	4
BLOOD_Leukemia	ITGAL →	+3.047	+0.311	.002	.005	3	3
KIDNEY	KCNK6 →	+1.558	+0.273	<.001	.009	2	4
STOMACH	PDE8B →	-0.773	-0.184	.003	.008	2	4
URINARY_TRACT	CBSL →	+2.356	+0.212	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050854 vs FICD — SOFT_TISSUE

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