B cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the B cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD48, RASAL3, and CD79A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell receptor signaling pathway activity versus CD48 in HNSC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD48 →	+1.060	+0.784	<.001	<.001	3	9
HNSC	RASAL3 →	+0.928	+0.683	<.001	<.001	3	8
HNSC	CD79A →	+1.773	+0.439	<.001	.004	3	8
HNSC	ITK →	+0.809	+0.393	<.001	<.001	3	8
LSCC	ZAP70 →	+1.113	+0.632	<.001	<.001	3	8
GBM	CCR2 →	+0.741	+0.140	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050853 vs CD48 — HNSC

Explore this scatter interactively →