B cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the B cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53BP2, ZNF544, and FASTKD3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP53BP2 grouped by B cell receptor signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TP53BP2 →	+1.069	+0.418	.002	<.001	3	3
LUNG_NSCLC_LUAD	ZNF544 →	+0.964	+0.580	.008	.007	3	3
KIDNEY	FASTKD3 →	+0.861	+1.053	<.001	.007	3	3
SOFT_TISSUE	LY9 →	-0.025	-1.013	.006	.001	3	3
PANCREAS	PLEKHN1 →	-1.109	-0.460	.005	.005	3	3
URINARY_TRACT	LRRC3 →	-1.115	-0.406	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP53BP2 by B cell receptor signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →