B cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the B cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC20, PSRC1, and PCBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell receptor signaling pathway activity versus H2AC20 in LARGE_INTESTINE (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2AC20 →	+0.870	+0.481	<.001	.002	3	5
OVARY	PSRC1 →	+0.607	+0.888	.004	.006	3	4
OVARY	PCBP1 →	+0.637	+1.581	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SCCPDH →	+1.538	+1.396	.005	.001	3	4
BLOOD_Lymphoma	FBXO32 →	-2.708	-0.219	.003	.002	3	4
BLOOD_Lymphoma	PDCD1LG2 →	-2.345	-0.291	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050853 vs H2AC20 — LARGE_INTESTINE

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