T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZAP70, SHFL, and NUMA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell receptor signaling pathway activity versus ZAP70 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZAP70 →	+0.523	+0.235	.004	.001	3	5
OV	SHFL →	+0.795	+0.274	<.001	.003	3	4
HNSC	NUMA1 →	-1.171	-0.381	<.001	<.001	3	4
COAD	CD5 →	+0.722	+0.301	.001	.004	3	4
CCRCC	FCRL3 →	+0.594	+0.192	<.001	.003	3	4
CCRCC	PDCD1 →	+0.775	+0.223	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050852 vs ZAP70 — CCRCC

Explore this scatter interactively →