T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPEB2, ADD1, and LGALS8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPEB2 grouped by T cell receptor signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CPEB2 →	-1.379	-0.197	<.001	<.001	3	5
BLOOD_Myeloma	ADD1 →	-1.133	-0.188	.007	.002	3	5
KIDNEY	LGALS8 →	+1.137	+0.284	.002	.002	3	4
CNS	FBRS →	-0.525	-0.165	<.001	.003	3	4
BREAST	ADIRF →	+4.115	+0.265	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ASCL5 →	-0.236	-0.115	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPEB2 by T cell receptor signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →