T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, TAP2, and TLE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell receptor signaling pathway activity versus PSMB9 in LUNG_SCLC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMB9 →	+2.872	+0.251	<.001	<.001	3	6
BREAST	TAP2 →	+1.521	+0.260	.001	.005	3	6
STOMACH	TLE2 →	-2.986	-0.294	.004	.003	3	5
LIVER	VIM →	+6.364	+0.252	.006	.001	2	6
LIVER	ZIK1 →	+1.935	+0.197	.004	.006	3	5
SOFT_TISSUE	TSC22D1 →	+1.406	+0.255	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050852 vs PSMB9 — LUNG_SCLC

Explore this scatter interactively →