Antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFFO1, MYO1G, and PARVG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen receptor-mediated signaling pathway activity versus IFFO1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IFFO1 →	+0.823	+0.257	.006	<.001	3	3
BRCA	MYO1G →	+0.968	+0.221	<.001	.001	3	3
BRCA	PARVG →	+1.141	+0.404	<.001	<.001	3	3
BRCA	PSTPIP1 →	+1.188	+0.276	<.001	<.001	3	3
BRCA	WAS →	+1.261	+0.331	<.001	<.001	3	3
BRCA	NCF1C →	+1.643	+0.346	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050851 vs IFFO1 — OV

Explore this scatter interactively →