Antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Antigen receptor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D10C, EFHD2, and GMIP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen receptor-mediated signaling pathway activity versus TBC1D10C in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBC1D10C →	+0.668	+0.291	<.001	<.001	3	3
BRCA	EFHD2 →	+0.851	+0.327	.001	.001	3	3
BRCA	GMIP →	+0.506	+0.329	<.001	<.001	3	3
BRCA	SEPTIN1 →	+1.019	+0.282	<.001	<.001	3	2
OV	SYNM_S653 →	+1.216	+0.268	.001	.001	3	2
BRCA	TBC1D25_S506 →	+1.231	+0.275	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050851 vs TBC1D10C — BRCA

Explore this scatter interactively →