Antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1-AS1, TAP1, and BTN3A3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen receptor-mediated signaling pathway activity versus IRF1-AS1 in BLOOD_Leukemia (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRF1-AS1 →	+1.749	+0.058	<.001	<.001	3	13
CNS	TAP1 →	+2.050	+0.055	<.001	<.001	3	12
BREAST	BTN3A3 →	+1.808	+0.063	<.001	.001	3	12
BONE	IRF1 →	+2.023	+0.082	<.001	<.001	3	11
SOFT_TISSUE	PSMB8 →	+2.925	+0.082	<.001	<.001	3	11
SOFT_TISSUE	TAPBP →	+1.946	+0.105	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050851 vs IRF1-AS1 — BLOOD_Leukemia

Explore this scatter interactively →