Progesterone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Progesterone receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NEDD4, S100A16, and TP53BP1_S598, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone receptor signaling pathway activity versus NEDD4 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NEDD4 →	+0.411	+0.043	.005	<.001	3	6
BRCA	S100A16 →	+0.594	+0.052	<.001	<.001	3	4
LSCC	TP53BP1_S598 →	+0.705	+0.051	.003	.005	3	4
BRCA	USP8 →	+0.213	+0.044	<.001	.003	3	4
BRCA	ATN1_S101 →	-0.479	-0.046	<.001	.007	3	4
GBM	SRC →	+0.303	+0.059	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050847 vs NEDD4 — OV

Explore this scatter interactively →