Progesterone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Progesterone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK, MAD2L1, and MMS22L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone receptor signaling pathway activity versus AHNAK in LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHNAK →	+0.662	+0.186	<.001	.003	3	4
CCRCC	MAD2L1 →	-0.370	-0.185	.001	<.001	3	4
BRCA	MMS22L →	-0.523	-0.214	.002	.003	3	4
LSCC	TENT5B →	+0.766	+0.141	<.001	<.001	3	4
HNSC	UGT8 →	-1.185	-0.195	<.001	<.001	3	4
UCEC	CEP72 →	-0.558	-0.223	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050847 vs AHNAK — LUAD

Explore this scatter interactively →