Defense response to fungus

Across TCGA patient cohorts, RNA activity of the Defense response to fungus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A8, PTPRC, and SAE1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to fungus activity versus S100A8 in LSCC (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	S100A8 →	+1.261	+0.074	<.001	<.001	3	8
GBM	PTPRC →	+0.688	+0.102	<.001	<.001	3	8
GBM	SAE1 →	-0.308	-0.073	<.001	<.001	3	8
GBM	RCSD1 →	+0.487	+0.094	<.001	<.001	3	7
LSCC	S100A9 →	+1.316	+0.077	<.001	<.001	3	7
UCEC	TBXAS1 →	+0.540	+0.065	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050832 vs S100A8 — LSCC

Explore this scatter interactively →