Defense response to fungus

Across TCGA patient cohorts, RNA activity of the Defense response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A8, FPR2, and BCL2A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to fungus activity versus S100A8 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S100A8 →	+2.566	+0.281	<.001	<.001	3	8
GBM	FPR2 →	+1.182	+0.222	<.001	<.001	3	8
GBM	BCL2A1 →	+1.465	+0.201	<.001	<.001	3	7
UCEC	FCGR3B →	+1.385	+0.263	<.001	<.001	3	7
UCEC	S100A9 →	+2.580	+0.224	<.001	<.001	3	7
LSCC	CXCR1 →	+0.863	+0.162	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050832 vs S100A8 — HNSC

Explore this scatter interactively →