Defense response to fungus

Across TCGA cell cohorts, RNA activity of the Defense response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP41, CASKIN1, and PPIA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP41 grouped by Defense response to fungus-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CEP41 →	-0.582	-0.268	.003	<.001	2	4
SKIN	CASKIN1 →	-0.407	-0.624	.003	.004	3	3
PANCREAS	PPIA →	-0.596	-0.917	.005	.005	3	3
BREAST	LZTS2 →	-0.556	-0.628	.007	.002	3	3
BREAST	OGFOD2 →	-0.844	-0.974	<.001	.001	3	3
LUNG_NSCLC_LUAD	NOP2 →	-0.677	-0.748	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP41 by Defense response to fungus activity — OESOPHAGUS

Explore this box plot interactively →