Defense response to fungus

Across TCGA cell cohorts, RNA activity of the Defense response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROC, QTRT1, and LAMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to fungus activity versus PROC in BLOOD_Lymphoma (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PROC →	-0.203	-0.150	.004	.005	3	5
URINARY_TRACT	QTRT1 →	+0.831	+0.280	.007	.001	3	4
STOMACH	LAMP2 →	-1.426	-0.242	<.001	.001	3	4
LUNG_NSCLC_LUAD	TRPV4 →	-0.880	-0.179	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SQOR →	+1.095	+0.142	.003	.002	3	4
KIDNEY	EIF2AK3 →	-1.537	-0.170	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050832 vs PROC — BLOOD_Lymphoma

Explore this scatter interactively →