Defense response to Gram-positive bacterium

Across TCGA cell cohorts, RNA activity of the Defense response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF10, ANAPC7, and XRCC2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to Gram-positive bacterium activity versus SRSF10 in BLOOD_Lymphoma (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SRSF10 →	-0.704	-0.123	<.001	<.001	3	11
BREAST	ANAPC7 →	-0.670	-0.137	<.001	<.001	3	11
BLOOD_Leukemia	XRCC2 →	-1.026	-0.112	<.001	<.001	3	10
BLOOD_Lymphoma	PPAT →	-0.832	-0.090	<.001	<.001	3	10
STOMACH	PARPBP →	-0.856	-0.134	<.001	<.001	3	10
BLOOD_Lymphoma	DAZAP1 →	-0.672	-0.087	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050830 vs SRSF10 — BLOOD_Lymphoma

Explore this scatter interactively →