Protein stabilization

Across TCGA patient cohorts, RNA activity of the Protein stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, TMOD2, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein stabilization activity versus SEPTIN4_S432 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.637	+0.029	.004	<.001	3	7
GBM	TMOD2 →	+0.386	+0.027	<.001	.001	3	7
CCRCC	RPL5 →	-0.167	-0.023	<.001	<.001	3	6
LSCC	MAP1LC3A →	+0.873	+0.034	<.001	<.001	3	6
HNSC	RPL18A_S123 →	-0.374	-0.055	<.001	.001	3	5
BRCA	SRPK1_S311 →	-0.549	-0.015	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050821 vs SEPTIN4_S432 — GBM

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