Protein stabilization

Across TCGA cell cohorts, RNA activity of the Protein stabilization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD274, TFIP11, and FBLIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD274 grouped by Protein stabilization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD274 →	+0.870	+0.123	.009	.004	3	5
UPPER_AERODIGESTIVE_TRACT	TFIP11 →	+0.848	+0.134	.002	.005	3	4
LUNG_SCLC	FBLIM1 →	+2.115	+0.167	.001	.003	3	4
BREAST	VXN →	+0.674	+0.093	.004	.002	3	4
SKIN	AKR7A2 →	-0.669	-0.092	.001	.001	3	4
KIDNEY	CREB5 →	+1.432	+0.184	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD274 by Protein stabilization activity — LUNG_SCLC

Explore this box plot interactively →