Positive regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Positive regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS35L, NIPBL, and CREB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS35L grouped by Positive regulation of coagulation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	VPS35L →	-1.597	-0.929	.003	.005	3	4
BLOOD_Myeloma	NIPBL →	+1.170	+1.325	.001	.001	3	4
KIDNEY	CREB1 →	+0.558	+1.213	.003	<.001	3	4
BLOOD_Myeloma	ATF7IP2 →	+2.728	+0.907	.001	.007	3	3
OVARY	DEAF1 →	+0.604	+1.037	<.001	.001	3	3
LARGE_INTESTINE	TRAPPC2B →	+2.040	+0.931	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS35L by Positive regulation of coagulation activity — PANCREAS

Explore this box plot interactively →