Positive regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Positive regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC28B, NDUFB10, and PCTP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of coagulation activity versus CCDC28B in SOFT_TISSUE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC28B →	+2.282	+1.630	.005	.001	3	4
LIVER	NDUFB10 →	+0.445	+0.430	.001	.007	3	4
LUNG_SCLC	PCTP →	-2.417	-0.319	<.001	<.001	3	4
LARGE_INTESTINE	AMOT →	-1.258	-0.463	.003	.001	3	4
SKIN	PRDX2 →	+3.909	+1.281	<.001	<.001	3	4
BREAST	DIXDC1 →	+0.887	+0.283	.009	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050820 vs CCDC28B — SOFT_TISSUE

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