Negative regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSB, RAD52, and MDN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSB grouped by Negative regulation of coagulation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARSB →	-0.921	-0.926	<.001	.001	3	4
LARGE_INTESTINE	RAD52 →	+0.729	+0.948	.005	.002	3	4
KIDNEY	MDN1 →	+0.583	+1.249	.005	<.001	3	4
KIDNEY	TMEM64 →	+0.810	+1.261	.003	.002	3	4
KIDNEY	HACD3 →	+0.784	+1.086	<.001	.004	3	4
KIDNEY	CAD →	+1.012	+1.176	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSB by Negative regulation of coagulation activity — CNS

Explore this box plot interactively →