Negative regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of coagulation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOSR2, CD24, and MLLT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOSR2 grouped by Negative regulation of coagulation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GOSR2 →	-0.141	-0.268	.003	<.001	3	5
LUNG_NSCLC_LUAD	CD24 →	+0.210	+0.169	.002	<.001	3	5
OVARY	MLLT3 →	-0.143	-0.120	.003	.006	3	5
URINARY_TRACT	PBX3 →	+0.305	+0.265	<.001	<.001	3	4
OESOPHAGUS	PCDHB2 →	-0.252	-0.176	.004	.002	3	4
OESOPHAGUS	SORL1 →	-0.102	-0.106	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOSR2 by Negative regulation of coagulation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →