Negative regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMM1, ARHGEF39, and SLC13A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of coagulation activity versus PMM1 in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PMM1 →	+0.838	+0.210	<.001	.009	3	5
OVARY	ARHGEF39 →	+1.131	+0.426	<.001	<.001	3	5
OVARY	SLC13A4 →	+0.748	+0.376	.002	.002	3	5
BLOOD_Leukemia	ZNF774 →	+0.487	+0.217	.007	.002	3	5
KIDNEY	MSS51 →	+0.668	+0.210	.003	.001	3	4
LUNG_NSCLC_LUSC	HNRNPA0 →	+0.841	+0.439	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050819 vs PMM1 — BLOOD_Lymphoma

Explore this scatter interactively →