Regulation of coagulation

Across TCGA patient cohorts, RNA activity of the Regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMP22, CD93, and THBD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of coagulation activity versus PMP22 in COAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PMP22 →	+0.825	+0.161	<.001	<.001	3	9
CCRCC	CD93 →	+0.755	+0.236	<.001	.001	3	9
GBM	THBD →	+1.256	+0.244	<.001	<.001	3	9
BRCA	COL15A1 →	+1.063	+0.353	<.001	<.001	3	9
COAD	SPARC →	+1.221	+0.208	<.001	<.001	3	8
GBM	LYVE1 →	+1.434	+0.256	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050818 vs PMP22 — COAD

Explore this scatter interactively →