Regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSF2, DET1, and OSGIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSF2 grouped by Regulation of coagulation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSF2 →	+0.821	+1.061	<.001	.001	2	5
PANCREAS	DET1 →	+0.801	+1.143	.002	.001	3	4
SKIN	OSGIN1 →	-1.395	-1.152	.001	.001	3	4
BLOOD_Leukemia	CCNB2 →	+0.635	+0.984	.001	.004	3	4
KIDNEY	SF3B1 →	+0.603	+0.898	.001	.008	3	4
PANCREAS	ANKMY2 →	+0.848	+0.951	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSF2 by Regulation of coagulation activity — LARGE_INTESTINE

Explore this box plot interactively →