Regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Regulation of coagulation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, P2RX7, and MAP3K8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Regulation of coagulation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TLN1 →	+0.405	+0.199	.001	<.001	2	7
LUNG_NSCLC_LUSC	P2RX7 →	+0.222	+0.180	.001	.001	3	6
LUNG_NSCLC_LUAD	MAP3K8 →	-0.135	-0.108	.006	.001	3	5
OESOPHAGUS	SOD1 →	+0.290	+0.166	.002	.002	3	5
LUNG_SCLC	ZNF621 →	+0.304	+0.181	.001	.001	3	5
BREAST	RAB3A →	-0.107	-0.118	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Regulation of coagulation activity — CNS

Explore this box plot interactively →