Regulation of coagulation

Across TCGA cell cohorts, RNA activity of the Regulation of coagulation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, MACC1, and DAPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of coagulation activity versus SGSM3 in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SGSM3 →	+0.727	+0.311	<.001	.001	3	5
OVARY	MACC1 →	-2.811	-0.274	<.001	<.001	3	5
OVARY	DAPP1 →	-2.070	-0.284	<.001	<.001	3	5
SOFT_TISSUE	DGLUCY →	+1.772	+0.270	.009	<.001	3	5
URINARY_TRACT	ZNF239 →	+1.562	+0.525	<.001	.001	3	5
LUNG_NSCLC_LUAD	JMJD4 →	-0.561	-0.230	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050818 vs SGSM3 — OVARY

Explore this scatter interactively →