Regulation of acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of acyl-CoA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDK2, RPS5, and SPTBN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acyl-CoA biosynthetic process activity versus PDK2 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDK2 →	+0.499	+0.103	<.001	<.001	3	5
GBM	RPS5 →	-0.143	-0.073	<.001	<.001	3	4
GBM	SPTBN1 →	+0.377	+0.088	<.001	<.001	3	4
GBM	GPT →	+0.738	+0.109	<.001	<.001	3	4
CCRCC	JUNB →	-0.432	-0.082	<.001	<.001	3	4
LSCC	LRP2_S4616 →	+0.598	+0.038	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050812 vs PDK2 — GBM

Explore this scatter interactively →