Regulation of acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KA4, MASP2, and PDK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acyl-CoA biosynthetic process activity versus RPS6KA4 in PDAC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPS6KA4 →	-0.244	-0.085	.001	.001	3	4
PDAC	MASP2 →	+0.324	+0.114	.001	.002	3	4
BRCA	PDK2 →	+0.963	+0.234	<.001	<.001	3	4
OV	STK17A →	-0.485	-0.159	<.001	<.001	2	5
LSCC	FCGR2A →	-0.576	-0.110	.002	<.001	3	4
PDAC	SGCA →	+0.449	+0.097	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050812 vs RPS6KA4 — PDAC

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