Regulation of acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of acyl-CoA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDK2, SIRT3, and PDHA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acyl-CoA biosynthetic process activity versus PDK2 in OV (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDK2 →	+0.606	+0.175	<.001	<.001	3	8
BRCA	SIRT3 →	+0.464	+0.191	.001	<.001	3	5
BRCA	PDHA1 →	+0.346	+0.179	.001	<.001	3	4
COAD	TIMM13 →	+0.387	+0.157	.002	.002	2	4
OV	TUBGCP6 →	-0.269	-0.162	.002	<.001	3	3
COAD	UQCC2 →	+0.440	+0.146	.004	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050812 vs PDK2 — OV

Explore this scatter interactively →