Regulation of acyl-CoA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of acyl-CoA biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDK2, SNCA, and PDK4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDK2 grouped by Regulation of acyl-CoA biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PDK2 →	-0.400	-1.624	.003	.002	3	11
LARGE_INTESTINE	SNCA →	-0.407	-1.344	.006	<.001	3	10
CNS	PDK4 →	-0.209	-0.728	<.001	<.001	3	9
PANCREAS	GOLGA4 →	-0.300	-1.694	.001	<.001	3	6
BLOOD_Leukemia	SRPK2 →	+0.256	+0.503	.002	.009	3	5
OESOPHAGUS	RAB21 →	-0.173	-1.230	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDK2 by Regulation of acyl-CoA biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →