Positive regulation of synaptic transmission

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COX4I1, SORCS2, and CHGB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic transmission activity versus COX4I1 in PDAC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	COX4I1 →	-0.417	-0.018	.001	<.001	3	6
BRCA	SORCS2 →	+0.686	+0.020	<.001	<.001	3	6
GBM	CHGB →	+0.636	+0.034	<.001	<.001	3	5
GBM	DNM1 →	+1.010	+0.056	<.001	<.001	3	5
BRCA	SEPTIN11 →	+0.243	+0.016	.005	<.001	3	5
UCEC	SORBS1 →	+0.917	+0.024	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050806 vs COX4I1 — PDAC

Explore this scatter interactively →