Positive regulation of synaptic transmission

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM10, SSBP2, and VASH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM10 grouped by Positive regulation of synaptic transmission-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RBM10 →	+0.375	+1.191	<.001	<.001	3	5
LIVER	SSBP2 →	+1.285	+1.192	.007	.004	3	4
STOMACH	VASH2 →	+1.193	+1.098	.002	.003	3	4
STOMACH	FAM171A2 →	+1.327	+0.950	.007	.002	3	4
STOMACH	HRH1 →	-2.043	-1.188	.005	.008	3	4
BLOOD_Lymphoma	TCIRG1 →	-0.716	-1.646	.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM10 by Positive regulation of synaptic transmission activity — STOMACH

Explore this box plot interactively →