Activated T cell proliferation

pathway activity — cross-omics
GO:0050798Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAG2, ARHGEF35, and HNRNPA3P12, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPRKAG2 →+0.504+0.127<.001.00833
UCECARHGEF35 →+0.814+0.196<.001.00733
CCRCCHNRNPA3P12 →-0.118-0.294.007.00633
CCRCCRN7SL351P →-0.441-0.379<.001<.00133
GBMWWC3 →-0.371-0.126<.001.00633
OVDTX3L →+0.835+0.155.002.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration