Regulation of insulin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX10, RPRD2, and WWC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of insulin secretion activity versus DDX10 in OESOPHAGUS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DDX10 →	-0.871	-0.189	.002	<.001	2	7
KIDNEY	RPRD2 →	+0.973	+0.262	.006	<.001	3	4
KIDNEY	WWC3 →	+1.491	+0.291	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	LIG3 →	-0.977	-0.220	.004	.005	3	4
STOMACH	POLR1G →	-1.300	-0.242	.007	<.001	3	4
STOMACH	AATF →	-0.624	-0.151	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050796 vs DDX10 — OESOPHAGUS

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