Regulation of behavior

Across TCGA patient cohorts, RNA activity of the Regulation of behavior pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3, LY6H, and IPCEF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of behavior activity versus RBMS3 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBMS3 →	+0.437	+0.771	<.001	<.001	3	4
GBM	LY6H →	+1.278	+0.828	<.001	<.001	3	4
GBM	IPCEF1 →	+0.562	+0.579	<.001	<.001	3	4
LSCC	ABCA8 →	+0.669	+0.909	.006	<.001	3	4
UCEC	AKR1B10 →	-1.431	-0.544	.003	.004	2	4
GBM	TMEM132D →	+0.718	+1.007	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050795 vs RBMS3 — LSCC

Explore this scatter interactively →