Regulation of viral process

Across TCGA cell cohorts, RNA activity of the Regulation of viral process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC61A2, CBX1, and PHF13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of viral process activity versus SEC61A2 in URINARY_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEC61A2 →	+0.846	+0.281	.004	<.001	3	6
PANCREAS	CBX1 →	+0.926	+0.149	.003	.003	3	6
LUNG_NSCLC_LUAD	PHF13 →	+0.705	+0.147	<.001	.004	3	6
LARGE_INTESTINE	HIP1 →	+1.177	+0.149	.005	.002	3	6
OVARY	WDR26 →	+0.974	+0.191	<.001	<.001	3	6
OVARY	SNX27 →	+0.775	+0.134	.007	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050792 vs SEC61A2 — URINARY_TRACT

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