RNA destabilization

Across TCGA patient cohorts, RNA activity of the RNA destabilization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UGDH_S476, PHLDB1_S419, and RPL26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA destabilization activity versus UGDH_S476 in CCRCC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	UGDH_S476 →	-0.526	-0.021	.004	<.001	3	5
HNSC	PHLDB1_S419 →	+0.635	+0.093	<.001	.003	3	5
HNSC	RPL26 →	-0.440	-0.117	<.001	.001	3	5
UCEC	LARP4B_S736 →	-0.523	-0.067	<.001	.008	3	5
HNSC	FAM83H →	-0.789	-0.092	<.001	.003	3	5
OV	RPL23A →	-0.588	-0.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050779 vs UGDH_S476 — CCRCC

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