RNA destabilization

Across TCGA cell cohorts, RNA activity of the RNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSZ, KLHL23, and STK17A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA destabilization activity versus CTSZ in BONE (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CTSZ →	-4.958	-0.196	.001	.004	3	6
BONE	KLHL23 →	+1.460	+0.185	.006	.004	3	6
BLOOD_Myeloma	STK17A →	-1.495	-0.161	.005	.005	3	5
BLOOD_Myeloma	EIF4EBP1 →	+1.571	+0.196	<.001	<.001	3	5
OVARY	LHX4 →	+0.484	+0.127	.005	<.001	3	5
BONE	ARRB2 →	+1.281	+0.213	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050779 vs CTSZ — BONE

Explore this scatter interactively →