Negative regulation of immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT3, PAPPA2, and C5AR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT3 grouped by Negative regulation of immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PLAAT3 →	+0.305	+0.130	.003	.008	3	4
LIVER	PAPPA2 →	+0.141	+1.469	.002	<.001	3	4
BLOOD_Myeloma	C5AR2 →	-0.512	-1.819	<.001	<.001	3	4
BLOOD_Myeloma	DHX29 →	+0.364	+1.509	<.001	<.001	3	4
BREAST	C11orf95 →	-0.411	-0.186	.004	<.001	3	4
LUNG_NSCLC_LUAD	COL8A2 →	-0.138	-0.312	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT3 by Negative regulation of immune response activity — CNS

Explore this box plot interactively →