Negative regulation of dendrite morphogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A11, PDGFD, and PDE2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendrite morphogenesis activity versus S100A11 in CCRCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	S100A11 →	-0.462	-0.633	.001	.001	3	4
CCRCC	PDGFD →	+0.820	+0.841	<.001	<.001	3	4
GBM	PDE2A →	+0.740	+0.793	.006	<.001	3	4
LSCC	CASP4LP →	+0.359	+0.509	.005	.003	2	5
LUAD	CAMTA1 →	+0.275	+0.577	.005	.005	3	4
CCRCC	AP3B2 →	-0.330	-0.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050774 vs S100A11 — CCRCC

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