Negative regulation of dendrite morphogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendrite morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAGB, CD200, and NGF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendrite morphogenesis activity versus RRAGB in LUNG_SCLC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRAGB →	+1.105	+0.393	<.001	.003	3	2
LUNG_SCLC	CD200 →	+4.538	+0.433	<.001	<.001	3	2
OVARY	NGF →	+2.888	+0.829	<.001	.005	3	2
LUNG_NSCLC_LUAD	RASL10A →	-0.480	-1.818	.004	<.001	3	2
LUNG_NSCLC_LUAD	TGFBR3L →	+1.827	+1.358	<.001	.004	3	2
CNS	AGO4 →	-0.827	-0.488	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050774 vs RRAGB — LUNG_SCLC

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