Regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Regulation of dendrite development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG20, SEPTIN11, and TNFAIP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite development activity versus ISG20 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ISG20 →	-0.640	-0.038	<.001	<.001	3	6
GBM	SEPTIN11 →	+0.257	+0.063	<.001	<.001	3	6
GBM	TNFAIP8 →	-0.530	-0.032	<.001	.001	3	6
GBM	LYAR →	-0.412	-0.061	<.001	<.001	3	6
GBM	ICAM3 →	-0.603	-0.041	<.001	<.001	3	6
GBM	IKBKG →	-0.200	-0.046	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050773 vs ISG20 — LSCC

Explore this scatter interactively →