Regulation of dendrite development

Across TCGA patient cohorts, RNA activity of the Regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA8, NUF2, and CDC20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite development activity versus CDCA8 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDCA8 →	-1.246	-0.753	<.001	.002	3	5
LUAD	NUF2 →	-1.371	-0.805	<.001	.001	3	5
LUAD	CDC20 →	-1.804	-0.765	<.001	.001	3	4
LUAD	HMGA1 →	-0.972	-0.662	<.001	.008	3	4
LUAD	CDCA5 →	-1.307	-0.747	<.001	.002	3	4
CCRCC	ZNF704 →	+0.781	+0.324	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050773 vs CDCA8 — LUAD

Explore this scatter interactively →