Regulation of dendrite development

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL10, ZNF33B, and CDC20B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite development activity versus ARL10 in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARL10 →	+1.156	+0.791	<.001	<.001	3	4
CNS	ZNF33B →	+0.554	+0.693	.004	.002	3	4
BLOOD_Myeloma	CDC20B →	+0.047	+1.349	.006	.001	3	4
LUNG_SCLC	EFNB3 →	+2.008	+1.169	.006	<.001	3	3
STOMACH	MFSD6 →	-1.587	-1.072	.001	.002	3	3
STOMACH	CHD9 →	+0.856	+0.929	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050773 vs ARL10 — OVARY

Explore this scatter interactively →