Positive regulation of axonogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEAK1, KBTBD2, and XPC-AS1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of axonogenesis activity versus PEAK1 in THYM (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PEAK1 →	+1.301	+0.056	<.001	<.001	3	32
THYM	KBTBD2 →	+0.822	+0.052	<.001	<.001	3	31
THYM	XPC-AS1 →	+0.766	+0.052	<.001	<.001	3	31
CHOL	RAB11FIP1P1 →	+1.364	+0.047	<.001	<.001	3	31
KIRC	YEATS2-AS1 →	+0.655	+0.040	<.001	<.001	3	31
ESCA	RN7SL81P →	+0.865	+0.052	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050772 vs PEAK1 — THYM

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